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Cerebellum. 2017 Feb;16(1):230-252. doi: 10.1007/s12311-016-0787-8.

The Roles of the Olivocerebellar Pathway in Motor Learning and Motor Control. A Consensus Paper.

Author information

1
Department of Neuroscience and Physiology, New York University School of Medicine, 550 1st Ave, New York, NY, USA. eric.lang@nyumc.org.
2
School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK.
3
Neural Basis for Sensorimotor Control, Department of Experimental Medical Science, Lund University, Lund, Sweden.
4
Department of Neuroscience, Erasmus MC Rotterdam, Dr. Molewaterplein 50, NL-3015 GE, Rotterdam, The Netherlands.
5
Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105 BA, Amsterdam, The Netherlands.
6
Department of Neuroscience, University of Minnesota, Minneapolis, MN, USA.
7
Department Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN, USA.
8
Department of Biology, Emory University, Atlanta, GA, USA.
9
Brain Information Communication Research Laboratory Group, ATR, Kyoto, Japan.
10
Department of Neurobiology and Integrated Center for Learning and Memory, Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
11
Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA, USA.
12
Department of Systems Neurophysiology, Graduate School of Medical and Dental Sciences, and Center for Brain Integration Research, Tokyo Medical and Dental University, Tokyo, Japan.
13
Department of Neuroscience and Physiology, New York University School of Medicine, 550 1st Ave, New York, NY, USA.

Abstract

For many decades, the predominant view in the cerebellar field has been that the olivocerebellar system's primary function is to induce plasticity in the cerebellar cortex, specifically, at the parallel fiber-Purkinje cell synapse. However, it has also long been proposed that the olivocerebellar system participates directly in motor control by helping to shape ongoing motor commands being issued by the cerebellum. Evidence consistent with both hypotheses exists; however, they are often investigated as mutually exclusive alternatives. In contrast, here, we take the perspective that the olivocerebellar system can contribute to both the motor learning and motor control functions of the cerebellum and might also play a role in development. We then consider the potential problems and benefits of it having multiple functions. Moreover, we discuss how its distinctive characteristics (e.g., low firing rates, synchronization, and variable complex spike waveforms) make it more or less suitable for one or the other of these functions, and why having multiple functions makes sense from an evolutionary perspective. We did not attempt to reach a consensus on the specific role(s) the olivocerebellar system plays in different types of movements, as that will ultimately be determined experimentally; however, collectively, the various contributions highlight the flexibility of the olivocerebellar system, and thereby suggest that it has the potential to act in both the motor learning and motor control functions of the cerebellum.

KEYWORDS:

Cerebellum; Complex spike; Inferior olive; Motor control; Motor learning; Purkinje cell; Synchrony

PMID:
27193702
PMCID:
PMC5116294
DOI:
10.1007/s12311-016-0787-8
[Indexed for MEDLINE]
Free PMC Article

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