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Sao Paulo Med J. 2016 May 13;134(3):234-9. doi: 10.1590/1516-3180.2015.01702312.

The effect of red grape seed extract on serum paraoxonase activity in patients with mild to moderate hyperlipidemia.

Author information

1
MD. Professor, Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
2
MSc, PhD. Professor, Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
3
MSc. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
4
MSc, PhD. Professor, Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
5
MSc. Doctoral Student, Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
6
MSc. Doctoral Student, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Abstract

CONTEXT AND OBJECTIVE:

Red grape seed extract (RGSE) contains oligomeric proanthocyanidin complexes as a class of flavonoids. These compounds are potent antioxidants and exert many health-promoting effects. This study aimed to determine the effects of RGSE on serum levels of triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein AI (apo-AI) levels and paraoxonase (PON) activity in patients with mild to moderate hyperlipidemia (MMH).

DESIGN AND SETTINGS:

A randomized double-blind placebo-controlled clinical trial was conducted at Shahid-Modarres Hospital (Tehran, Iran) and Tabriz University of Medical Sciences. Seventy MMH patients were randomly assigned to receive treatment (200 mg/day of RGSE) or placebo for eight weeks.

RESULTS:

Significant elevation in serum levels of apo-AI (P = 0.001), HDL-C (P = 0.001) and PON activity (P = 0.001) and marked decreases in concentrations of TC (P = 0.015), TG (P = 0.011) and LDL-C (P = 0.014) were found in the cases. PON activity was significantly correlated with apo-AI (r = 0.270; P < 0.01) and HDL-C (r = 0.45; P < 0.001). Significant differences between the RGSE and control groups (before and after treatment) for TC (P = 0.001), TG (P = 0.001), PON (P = 0.03), apo-AI (P = 0.001) and LDL-C (P = 0.002) were seen.

CONCLUSION:

It is possible that RGSE increases PON activity mostly through increasing HDL-C and apo-AI levels in MMH patients. It may thus have potential beneficial effects in preventing oxidative stress and atherosclerosis in these patients.

PMID:
27191247
DOI:
10.1590/1516-3180.2015.01702312
[Indexed for MEDLINE]
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