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Exp Biol Med (Maywood). 2016 May;241(10):1025-32. doi: 10.1177/1535370216648023. Epub 2016 May 4.

Creating biomaterials with spatially organized functionality.

Author information

1
Department of Materials Science and Engineering, Lehigh University, Bethlehem, PA 18015, USA Bioengineering Program, Lehigh University, Bethlehem, PA 18015, USA lesley.chow@lehigh.edu.
2
Bioengineering Program, Lehigh University, Bethlehem, PA 18015, USA.

Abstract

Biomaterials for tissue engineering provide scaffolds to support cells and guide tissue regeneration. Despite significant advances in biomaterials design and fabrication techniques, engineered tissue constructs remain functionally inferior to native tissues. This is largely due to the inability to recreate the complex and dynamic hierarchical organization of the extracellular matrix components, which is intimately linked to a tissue's biological function. This review discusses current state-of-the-art strategies to control the spatial presentation of physical and biochemical cues within a biomaterial to recapitulate native tissue organization and function.

KEYWORDS:

Biomaterials; biomedical; extracellular matrix; regenerative medicine; tissue engineering; translational

PMID:
27190258
PMCID:
PMC4950364
DOI:
10.1177/1535370216648023
[Indexed for MEDLINE]
Free PMC Article

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