Format

Send to

Choose Destination
Genome Biol Evol. 2016 May 13;8(5):1388-400. doi: 10.1093/gbe/evw077.

"Every Gene Is Everywhere but the Environment Selects": Global Geolocalization of Gene Sharing in Environmental Samples through Network Analysis.

Author information

1
Laboratory of Microbial and Molecular Evolution, Department of Biology, University of Florence, Italy Computational Biology Group, University of Florence, Italy.
2
Department of Food and Environmental Sciences, University of Helsinki, Finland.
3
Department of Environmental Systems Science, ETH Zürich, Switzerland Department of Aquatic Ecology, Eawag, Switzerland.
4
Department of Civil and Environmental Engineering, Massachusetts Institute of Technology.
5
Department of Biology, National University of Ireland Maynooth, County Kildare, Ireland Computational Evolutionary Biology, Faculty of Life Sciences, The University of Manchester, United Kingdom james.mcinerney@manchester.ac.uk.

Abstract

The spatial distribution of microbes on our planet is famously formulated in the Baas Becking hypothesis as "everything is everywhere but the environment selects." While this hypothesis does not strictly rule out patterns caused by geographical effects on ecology and historical founder effects, it does propose that the remarkable dispersal potential of microbes leads to distributions generally shaped by environmental factors rather than geographical distance. By constructing sequence similarity networks from uncultured environmental samples, we show that microbial gene pool distributions are not influenced nearly as much by geography as ecology, thus extending the Bass Becking hypothesis from whole organisms to microbial genes. We find that gene pools are shaped by their broad ecological niche (such as sea water, fresh water, host, and airborne). We find that freshwater habitats act as a gene exchange bridge between otherwise disconnected habitats. Finally, certain antibiotic resistance genes deviate from the general trend of habitat specificity by exhibiting a high degree of cross-habitat mobility. The strong cross-habitat mobility of antibiotic resistance genes is a cause for concern and provides a paradigmatic example of the rate by which genes colonize new habitats when new selective forces emerge.

KEYWORDS:

antibiotic resistance; biogeography; horizontal gene transfer

PMID:
27190206
PMCID:
PMC4898794
DOI:
10.1093/gbe/evw077
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Silverchair Information Systems Icon for PubMed Central
Loading ...
Support Center