Send to

Choose Destination
J Pediatr. 2016 Aug;175:159-166.e2. doi: 10.1016/j.jpeds.2016.04.064. Epub 2016 May 14.

Effects of Perinatal Dioxin Exposure on Development of Children during the First 3 Years of Life.

Author information

Biomedical and Pharmaceutical Research Center, Vietnam Military Medical University, Ha Dong, Ha Noi, Vietnam. Electronic address:
Department of Epidemiology and Public Health, Kanazawa Medical University, Uchinada, Ishikawa, Japan.
Biomedical and Pharmaceutical Research Center, Vietnam Military Medical University, Ha Dong, Ha Noi, Vietnam.
System Emotional Science, Graduate School of Medicine, University of Toyama, Toyama, Japan.



To investigate the longitudinal effects of perinatal exposure to dioxin on neurodevelopment and physical growth of a birth cohort during the first 3 years of life.


A total of 217 mother-infant pairs living in a dioxin-contaminated area in Vietnam were followed up. Perinatal dioxin exposure of infants was estimated by the measurement of dioxin levels in breast milk of nursing mothers. Neurodevelopment of infants and children, including cognitive, language, and motor development, was determined at 4 months, 1 year, and 3 years of age. Physical growth, including weight, height, and head and abdominal circumferences, was measured at birth, 1 and 4 months, and 1 and 3 years of age. Multivariate mixed models were applied for analyzing repeated measures.


In boys, composite motor and gross motor scores were decreased with increasing exposure of 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TetraCDD). The high toxic equivalent of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDDs/PCDFs-TEQ) group showed a significant decrease in expressive communication score. In girls, there was no decreased score in any neurodevelopment aspects in high-exposure groups. All body size measures in boys were decreased in the high-exposure groups of 2,3,7,8-TetraCDD and PCDDs/PCDFs-TEQ. In girls, high 2,3,7,8-TetraCDD and PCDDs/PCDFs-TEQ exposure was associated with increased head and abdominal circumferences.


Perinatal dioxin exposure affects physical growth and neurodevelopment of infants and children in the first 3 years of life in a sex-specific manner.


herbicides; neurodevelopment; physical growth

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center