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Gynecol Endocrinol. 2016 Oct;32(10):831-834. Epub 2016 May 17.

Improvement of quality of life and menopausal symptoms in climacteric women treated with low-dose monthly parenteral formulations of non-polymeric microspheres of 17β-estradiol/progesterone.

Author information

1
a Instituto Nacional de Perinatología "Isidro Espinosa de los Reyes" , Ciudad de México , México.
2
b Centro A.F. de Estudios Tecnológicos , S.A. de C.V. (CAFET), Ciudad de México , México.
3
c Unidad de Investigación Epidemiológica y en Servicios de Salud, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social , Ciudad de México , México , and.
4
d Facultad de Ciencias Médicas , Instituto de Biomedicina, Área de Investigación para la Salud de la Mujer, Universidad Católica de Santiago de Guayaquil , Guayaquil , Ecuador.

Abstract

OBJECTIVE:

To evaluate the short term effect over menopausal symptoms and quality of life (QoL) of monthly parenteral formulations of 17β-estradiol (E)/progesterone (P) non-polymeric microspheres.

METHODS:

This is a secondary analysis of a multicenter, randomized, single-blinded study that included peri- and post-menopausal symptomatic women assigned to receive a monthly intramuscular injection of 0.5 mg E + 15 mg P (Group A, n = 34), 1 mg E + 20 mg P (Group B, n = 24), or 1 mg E + 30 mg P (Group C, n = 26) for 6 months. Intensity of menopausal symptoms was assessed before and after treatment with the Greene Climacteric Scale (GCS) and QoL with the Utian Quality of Life Scale (UQoLS).

RESULTS:

Menopausal symptoms improved for all groups at six months evidenced by lower cluster/sub-cluster GCS scores. Equally, there was an overall trend for QoL improvement for all groups evidenced by higher domain UQoLS scores at six months; but only significant for the emotional (Groups A and B) and occupational domains (Groups A and C).

CONCLUSION:

The three low-dose continuous sequential intramuscular monthly formulations of E/P microspheres exerted a positive effect over menopausal symptoms and QoL. Long-term research is warranted with these formulations.

CLINICAL TRIAL REGISTRATION:

Clinicaltrials.gov Identifiers NCT 00775242.

KEYWORDS:

Climacteric; Greene Climacteric Scale; Utian Quality of Life Scale; estradiol; menopausal symptoms; non polymeric microspheres; quality of life

PMID:
27187320
DOI:
10.1080/09513590.2016.1183628
[Indexed for MEDLINE]

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