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Niger Med J. 2016 Jan-Feb;57(1):19-23. doi: 10.4103/0300-1652.180566.

Management of ovarian cysts with percutaneous aspiration and methotrexate injection.

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Department of Gynecology and Obstetrics, PGIMSR, Basai Darapur, New Delhi, India.
Department of Gynecology and Obstetrics, Government Medical College, Chandigarh, India.



To evaluate ultrasonographic-guided cyst aspiration and methotrexate injection in the management of simple and endometriotic ovarian cysts in selected patients.


This prospective study was conducted in the Department of Obstetrics and Gynaecology in Government Medical College and Hospital, Chandigarh, from November 2007 to October 2009. It included 132 female patients (age range, 15-72 years; mean, 38.7 years) with simple or endometriotic ovarian cysts (3.0-10.6 cm) at ultrasonic examinations. We performed puncture and aspiration followed by methotrexate injection into the cyst. All patients were followed for 12 months. None was lost to follow-up.


At follow-up ultrasonography, cysts had disappeared in 120 patients (90.90%) and persisted in 12 patients (9%). No major complications were observed in our study population during or after the procedure. Only 10 patients reported mild pelvic pain, and four others reported dizziness or nausea during or after the procedure. Malignant cells were not found in any of the cases at cytologic examination. We did not observe any cases of infection after the procedure.


Ultrasonography-guided transabdominal aspiration of cyst fluid and subsequent methotrexate injection appears to be an alternative treatment for both simple and endometriotic ovarian cysts in selected cases.


Aspiration; methotrexate; ovarian cyst; ultrasonography

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