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Vox Sang. 2016 Oct;111(3):315-319. doi: 10.1111/vox.12413. Epub 2016 May 17.

Prevalence of RHD alleles in Japanese individuals with weak D phenotype: Identification of 20 new RHD alleles.

Author information

1
Japanese Red Cross Central Blood Institute, Tokyo, Japan.
2
Japanese Red Cross Central Blood Institute, Tokyo, Japan. k-ogasawara@jrc.or.jp.
3
Japanese Red Cross Kanto-Koshinetsu Block Blood Center, Tokyo, Japan.

Abstract

We identified 46 different RHD alleles from 226 Japanese individuals with weak D phenotype, 26 of which had been previously described and 20 that were novel. Among these weak D individuals, the alleles with c.960G>A, c.845G>A (RHD*15) or c.1013T>C (RHD*01W.24) mutations were most prevalent with relative occurrences of 36·7%, 15·9% and 9·7%, respectively. These findings demonstrate that the prevalence of common weak D alleles in the Japanese population significantly differs from that of Caucasian populations.

KEYWORDS:

RHD gene; Rh blood group; weak D

PMID:
27183894
DOI:
10.1111/vox.12413
[Indexed for MEDLINE]

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