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J Am Acad Dermatol. 2016 Jul;75(1):151-4. doi: 10.1016/j.jaad.2016.02.1234. Epub 2016 May 13.

Cardiovascular risk in patients with alopecia areata (AA): A propensity-matched retrospective analysis.

Author information

1
Department of Dermatology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
2
Department of Biostatistics and Bioinformatics, Tulane University, New Orleans, Louisiana.
3
Department of General and Internal Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
4
Department of Dermatology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. Electronic address: amostaghimi@bwh.harvard.edu.

Abstract

BACKGROUND:

The cardiovascular risk of patients with alopecia areata (AA) is not well characterized, with limited studies evaluating the risk of acute myocardial infarction (AMI) and ischemic stroke.

OBJECTIVE:

We sought to determine the risk for patients with AA to develop subsequent stroke and AMI.

METHODS:

We conducted propensity-matched retrospective analysis between January 1, 2000, and January 1, 2010, from Brigham and Women's Hospital and Massachusetts General Hospital in Boston, MA. A comprehensive research patient data repository search was done for International Classification of Diseases, Ninth Revision code 704.01 and cases were verified using a natural language processing program. Propensity score matching was used to identify controls for AA cases based on age, race, gender, smoking status, and history of hypertension, diabetes, and hyperlipidemia.

RESULTS:

We identified 1377 cases of AA matched with 4131 controls. Patients with AA had decreased odds for developing stroke (odds ratio 0.39, 95% CI 0.18-0.87) and a trend toward decreased risk of AMI (odds ratio 0.91, 95% CI 0.59-1.39).

LIMITATIONS:

This was a retrospective study using a clinical database.

CONCLUSION:

Patients with AA had decreased risk for stroke and AMI, although not statistically significant. Further studies are needed to confirm these findings in other AA cohorts and to elucidate a potential mechanism.

KEYWORDS:

alopecia; alopecia areata; cardiovascular risk; metabolic risk; myocardial infarction; stroke

PMID:
27183846
DOI:
10.1016/j.jaad.2016.02.1234
[Indexed for MEDLINE]

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