Format

Send to

Choose Destination
Nat Methods. 2016 Jul;13(7):569-72. doi: 10.1038/nmeth.3866. Epub 2016 May 16.

Flyception: imaging brain activity in freely walking fruit flies.

Author information

1
Kavli Institute for Brain and Mind, University of California, San Diego, La Jolla, California, USA.
2
Division of Biological Sciences, University of California, San Diego, La Jolla, California, USA.
3
Department of Cognitive Science, University of California, San Diego, La Jolla, California, USA.

Abstract

Genetically encoded calcium sensors have enabled monitoring of neural activity in vivo using optical imaging techniques. Linking neural activity to complex behavior remains challenging, however, as most imaging systems require tethering the animal, which can impact the animal's behavioral repertoire. Here, we report a method for monitoring the brain activity of untethered, freely walking Drosophila melanogaster during sensorially and socially evoked behaviors to facilitate the study of neural mechanisms that underlie naturalistic behaviors.

PMID:
27183441
DOI:
10.1038/nmeth.3866
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center