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Bone Marrow Transplant. 2016 Jul;51(7):906-12. doi: 10.1038/bmt.2016.130. Epub 2016 May 16.

Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a new classification from the European Society for Blood and Marrow Transplantation.

Author information

1
Hematology Department, Hôpital Saint Antoine, and Université Pierre & Marie Curie, Paris, France.
2
Instituto Portugues de Oncologia, Lisbon, Portugal.
3
Department of Haematology, University Hospital Zurich, Zurich, Switzerland.
4
King Abdullah International Medical Research Center/King Saud Bin Abdulaziz University for Health Sciences, Department of Oncology, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.
5
King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
6
Sisli Florence Nightingale Hospital, HSCT Unit, Istanbul, Turkey.
7
Division for Stem Cell Transplantation and Immunology, Department for Children and Adolescents, University Hospital, Goethe University, Frankfurt/Main, Germany.
8
Department of Hematology, University of Liege, Liege, Belgium.
9
Department of Internal Medicine, American University of Beirut, Beirut, Lebanon.
10
Blood and Marrow Transplantation Program, Hematology Department, Institut Paoli-Calmettes, Marseille, France.
11
Hematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, Milano, Italy.
12
Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, University of Regensburg, Regensburg, Germany.
13
Department of Hematology and Immunology, Hospital Robert Debre, Paris 7-Paris Diderot University, Paris, France.
14
Department of Clinical Haematology, Central Manchester Foundation Trust, Manchester, UK.
15
HSCT division, National Cancer Center Hospital, Tokyo, Japan.
16
Hematology Department, Institut Universitaire du Cancer Toulouse - Oncopole, Toulouse, France.
17
Department of Hematology and Stem Cell Transplantation, St Istvan and St Laszlo Hospital, Budapest 3 Department of Internal Medicine, Semmelweis University, Budapest, Hungary.
18
Hematology Department, Groupement Hospitalier Sud, Hospices Civils de Lyon, Université Claude Bernard Lyon EST, Pierre Bénite, France.
19
Hematology and Bone Marrow Transplantation, Chaim Sheba Medical center, Tel-Hashomer, Israel.
20
National Stem Cell Transplant Unit (Adults), Department of Haematology, St James's Hospital and Academic Department of Haematology, Trinity College Dublin, Dublin, Ireland.
21
Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
22
Department of Haematology, King's College Hospital, London, UK.
23
Department of Pediatrics, St Anna Kinderspital, Vienna, Austria.
24
LDS Hospital, Salt Lake City, UT, USA.
25
Division of Hematologic Malignancy, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
26
Comprehensive Cancer Center, Helsinki University Hospital, Helsinki, Finland.
27
Hematology and Stem Cell Transplantation Section, Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center and Veterans Affairs Medical Center, Nashville, Tennessee.
28
Section of Haematology and Coagulation, Department of Internal Medicine, Sahlgrenska University Hospital, Göteborg Sweden.
29
CHU de Lille, LIRIC INSERM U995, université de Lille2, France.
30
Department of Hematology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain.
31
Josep Carreras Foundation & Leukemia Research Institute, Hematology Department, Hospital Clínic, Barcelona, Spain.

Abstract

Sinusoidal obstruction syndrome, also known as veno-occlusive disease (SOS/VOD), is a potentially life threatening complication that can develop after hematopoietic cell transplantation. Although SOS/VOD progressively resolves within a few weeks in most patients, the most severe forms result in multi-organ dysfunction and are associated with a high mortality rate (>80%). Therefore, careful attention must be paid to allow an early detection of SOS/VOD, particularly as drugs have now proven to be effective and licensed for its treatment. Unfortunately, current criteria lack sensitivity and specificity, making early identification and severity assessment of SOS/VOD difficult. The aim of this work is to propose a new definition for diagnosis, and a severity-grading system for SOS/VOD in adult patients, on behalf of the European Society for Blood and Marrow Transplantation.

PMID:
27183098
PMCID:
PMC4935979
DOI:
10.1038/bmt.2016.130
[Indexed for MEDLINE]
Free PMC Article

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