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Nat Neurosci. 2016 Jul;19(7):959-64. doi: 10.1038/nn.4304. Epub 2016 May 16.

Hippocampo-cortical coupling mediates memory consolidation during sleep.

Maingret N1,2,3,4, Girardeau G1,2,3,4, Todorova R1,2,3,4, Goutierre M1,2,3,4, Zugaro M1,2,3,4.

Author information

1
Collège de France, Center for Interdisciplinary Research in Biology (CIRB), Paris, France.
2
CNRS UMR 7241, Paris, France.
3
INSERM U1050, Paris, France.
4
PSL Research University, Paris, France.

Abstract

Memory consolidation is thought to involve a hippocampo-cortical dialog during sleep to stabilize labile memory traces for long-term storage. However, direct evidence supporting this hypothesis is lacking. We dynamically manipulated the temporal coordination between the two structures during sleep following training on a spatial memory task specifically designed to trigger encoding, but not memory consolidation. Reinforcing the endogenous coordination between hippocampal sharp wave-ripples, cortical delta waves and spindles by timed electrical stimulation resulted in a reorganization of prefrontal cortical networks, along with subsequent increased prefrontal responsivity to the task and high recall performance on the next day, contrary to control rats, which performed at chance levels. Our results provide, to the best of our knowledge, the first direct evidence for a causal role of a hippocampo-cortical dialog during sleep in memory consolidation, and indicate that the underlying mechanism involves a fine-tuned coordination between sharp wave-ripples, delta waves and spindles.

PMID:
27182818
DOI:
10.1038/nn.4304
[Indexed for MEDLINE]

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