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Rare Cancers Ther. 2015;3:1-11. Epub 2015 Jul 4.

Acute Myeloid Leukemia in the Elderly Patient: New Strategies.

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Hematology Department, Hospices Civils de Lyon, Lyon-Sud Hospital, Bât.1G, Pierre-Bénite, France.


Although selected older adults with acute myeloid leukemia can benefit from intensive therapies, recent evidences support the use of lower-intensity therapies (hypomethylating agents or low-dose cytarabine) in most of these patients and emphasize the importance of tolerability and quality of life. Individualized approaches to treatment decision-making beyond consideration of chronologic age alone should therefore be considered. One promising strategy is to combine low-intensity treatments with novel agents.


Acute myeloid leukemia; Chemotherapy; Elderly; Hypomethylating agents; Supportive care; Targeted therapy

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