Format

Send to

Choose Destination
Curr Opin Virol. 2016 Jun;18:76-81. doi: 10.1016/j.coviro.2016.04.002. Epub 2016 May 12.

Zika crisis in Brazil: challenges in research and development.

Author information

1
Department of Microbiology, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; Immunopharmacology, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
2
Immunopharmacology, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
3
Laboratório de Biologia Molecular and Programa de Pós Graduação em Ciências da Saúde, Hospital Universitário, Universidade Federal de Sergipe, Aracaju, Brazil.
4
Immunopharmacology, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Electronic address: mmtex@icb.ufmg.br.

Abstract

Infection with the Zika virus (ZIKV) usually causes a mild acute illness, but two major severe syndromes have been described during the epidemic in Brazil: microcephaly and the Guillain-Barré Syndrome. There is now much evidence to show that ZIKV can infect and damage neuronal cells in vitro. In experimental animals, ZIKV has significant neurotropism and can cause brain damage. At present, diagnosis is still a challenge in the field and there is no treatment available. Another major challenge is that one must devise therapies for pregnant women, at all stages of pregnancy. Devising adequate treatment for ZIKV infections represents a challenge that will only be met by the joint effort of the research community.

PMID:
27179929
DOI:
10.1016/j.coviro.2016.04.002
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center