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Radiother Oncol. 2016 Jun;119(3):519-24. doi: 10.1016/j.radonc.2016.04.020. Epub 2016 May 11.

Motion management during SBRT for oligometastatic cancer: Results of a prospective phase II trial.

Author information

1
Department of Radiotherapy, UZ Brussel, Vrije Universiteit Brussel, Belgium.
2
Department of Radiology, UZ Brussel, Vrije Universiteit Brussel, Belgium.
3
Department of Radiotherapy, UZ Brussel, Vrije Universiteit Brussel, Belgium. Electronic address: Mark.DeRidder@uzbrussel.be.

Abstract

PURPOSE:

To optimize the local control of stereotactic body radiotherapy (SBRT) using the Vero-SBRT system and respiratory motion management in patients with oligometastatic cancer.

MATERIALS AND METHODS:

Patients with five or less metastases were eligible. In metastases with significant motion, a fiducial was implanted for Vero dynamic tracking. For other metastases an internal target volume (ITV) was defined to encompass the respiratory tumor trajectory. A dose of 50Gy in 10 fractions was prescribed on the 80% isodose line.

RESULTS:

We treated 87 metastases in 44 patients, with colorectal cancer as the most common primary origin (65.9%). Metastatic sites were mainly lung (n=62) and liver (n=17). Twenty-seven metastases were treated with dynamic tracking, the remaining 60 using the ITV-concept. Three patients (7%) experienced grade ⩾3 toxicity. After a median follow-up of 12months, the overall one-year local control (LC) amounted to 89% (95% CI 77-95%), with corresponding values of 90% and 88% for the metastases irradiated with the ITV-approach and dynamic tracking, respectively. Median progression-free survival reached 6.5months, one-year overall survival 95%.

CONCLUSIONS:

SBRT with proper respiratory motion management resulted in a high LC and an acceptable toxicity profile in oligometastatic cancer patients.

KEYWORDS:

Motion management; Oligometastases; SBRT; Tomotherapy; Vero

PMID:
27179921
DOI:
10.1016/j.radonc.2016.04.020
[Indexed for MEDLINE]

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