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J Gastroenterol. 2017 Apr;52(4):432-443. doi: 10.1007/s00535-016-1224-y. Epub 2016 May 13.

Efficacy of double-coated probiotics for irritable bowel syndrome: a randomized double-blind controlled trial.

Author information

1
Department of Rehabilitation Medicine of Korean Medicine, Dongguk University Ilsan Hospital, 814 Siksa-dong, Goyang, Gyeonggi-do, Republic of Korea.
2
R&D Center, Cell Biotech Co. Ltd., Gimpo, 415-871, Republic of Korea.
3
Department of Rehabilitation Medicine of Korean Medicine, Dongguk University Ilsan Hospital, 814 Siksa-dong, Goyang, Gyeonggi-do, Republic of Korea. kimklar@dongguk.ac.kr.

Abstract

BACKGROUND:

The purpose of this study was to elucidate the effects of a dual-coated probiotic supplement (Duolac Care) on symptoms of diarrhea-predominant irritable bowel syndrome in a randomized double-blind clinical trial.

METHODS:

Fifty subjects with diarrhea-predominant irritable bowel syndrome were randomly assigned to either the non-coating group or the dual-coating group in order to receive two capsules per day of multi-species probiotics containing 5 billion bacteria per capsule for 4 weeks. Data from an adequate relief questionnaire were used in assessment of primary outcome. Daily records of stool frequencies and the Bristol stool scale, a weekly symptom diary using 100-mm visual analog scale, and Beck depression inventories were collected. Blood tests including blood cell counts, interleukin-10, tumor necrosis factor-alpha and inducible nitric oxide synthase, and regulatory T cells-CD4 + CD25high T cells, CD4 + LAP + T cells and CD25high + LAP + T cells-were analyzed before and after the study. The shift of gut microbiota was investigated using a quantitative real-time polymerase chain reaction assay.

RESULTS:

Responses to the adequate relief questionnaire indicated significant improvement in overall discomfort in the dual-coating group and the ratio of normal stools to hard or watery stools had a better effect from dual-coated probiotics compared to non-coated probiotics. This may be due to a shift of intestinal microbiota, as our correlation analysis showed significant negative correlation between Bifidobacterium and urgency of defecation.

CONCLUSIONS:

Our result implies that dual-coating layers of probiotic supplement can be a candidate for treatment of diarrhea-predominant irritable bowel syndrome.

KEYWORDS:

Dual-coating technology; Irritable bowel syndrome; Probiotics

PMID:
27178566
DOI:
10.1007/s00535-016-1224-y
[Indexed for MEDLINE]

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