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Semin Immunopathol. 2016 Sep;38(5):549-61. doi: 10.1007/s00281-016-0567-z. Epub 2016 May 13.

New insights into basophil heterogeneity.

Oetjen LK1,2,3, Noti M4, Kim BS5,6,7,8,9.

Author information

1
Division of Dermatology, Department of Medicine, Washington University School of Medicine, 660 S. Euclid Avenue, Box 8123, St. Louis, MO, 63110, USA.
2
Center for the Study of Itch, Washington University School of Medicine, St. Louis, MO, USA.
3
Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, MO, USA.
4
Division of Experimental Pathology, Institute of Pathology, University of Bern, Bern, Switzerland.
5
Division of Dermatology, Department of Medicine, Washington University School of Medicine, 660 S. Euclid Avenue, Box 8123, St. Louis, MO, 63110, USA. briankim@wustl.edu.
6
Center for the Study of Itch, Washington University School of Medicine, St. Louis, MO, USA. briankim@wustl.edu.
7
Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, MO, USA. briankim@wustl.edu.
8
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA. briankim@wustl.edu.
9
Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, USA. briankim@wustl.edu.

Abstract

Basophils have become increasingly recognized as important innate immune cells that mediate antihelminth immunity and barrier inflammation. Recent discoveries have uncovered previously unrecognized heterogeneity in basophil populations. However, how diversity in basophil regulation and function impacts human disease remains poorly defined. The goal of the present review is to highlight how new insights into basophil heterogeneity can help us to better understand disease pathogenesis and inform the development of new therapeutics.

PMID:
27178409
PMCID:
PMC5010479
DOI:
10.1007/s00281-016-0567-z
[Indexed for MEDLINE]
Free PMC Article

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