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Trop Doct. 2017 Jan;47(1):77-84. Epub 2016 May 13.

Vitamin D deficiency and lower respiratory tract infections in children: a systematic review and meta-analysis of observational studies.

Author information

1
Assistant Professor, Department of Paediatrics, All India Institute of Medical Sciences, New Delhi, India drkanaram@gmail.com.

Abstract

Studies related to vitamin D deficiency and lower respiratory tract infections (LRTI) in children have inconsistent findings. The objective of this systematic review was to assess the prevalence of vitamin D deficiency in children with LRTI, and to evaluate the correlation between vitamin D levels and the incidence and severity of LRTI. A total of 12 studies enrolling 2279 participants were included in our analysis. Children with LRTI were found to have significantly lower mean vitamin D levels as compared to controls There was likewise a correlation between vitamin D levels and incidence and severity of LRTI. Large randomised controlled trials are needed to evaluate effect of vitamin D supplementation for LRTI.

KEYWORDS:

Vitamin D; case-control study; cohort; lower respiratory tract infection (LRTI)

PMID:
27178217
DOI:
10.1177/0049475516644141
[Indexed for MEDLINE]

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