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J Neurosurg Spine. 2016 Oct;25(4):523-527. Epub 2016 May 13.

Multifocal granulocytic sarcoma of the spine mimicking neurofibromatosis Type 2: case report.

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House Clinic; and.
Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, California.


In this report the authors report on a patient with a very indolent course of granulocytic sarcoma, characterized by steroid-induced remission of spinal and cranial tumors and recurrence over a period of several years. This 24-year-old man with history of leukemia presented with rapid-onset quadriparesis secondary to multiple extraaxial masses of the cervicothoracic spine, from C-5 to T-3, and lumbosacral spine, from L-5 to the coccyx. Although the imaging features were highly suggestive of neurofibromatosis Type 2, the patient's history and clinical course were consistent with granulocytic sarcoma; repeat imaging and, later, needle biopsy definitively established the diagnosis of granulocytic sarcoma. Laminectomy and surgical decompression of the spine were not required and, arguably, could have posed unnecessary risk to the patient. This case illustrates that the successful management of a patient presenting with profound neurological deficits due to intradural spinal cord tumors may sometimes be nonsurgical.


CPA = cerebellopontine angle; GS = granulocytic sarcoma; NF2 = neurofibromatosis Type 2; chloroma; granulocytic sarcoma; neurofibromatosis; oncology; spine

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