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Circ Res. 2016 May 13;118(10):1612-25. doi: 10.1161/CIRCRESAHA.116.307473.

Dietary Interventions, Cardiovascular Aging, and Disease: Animal Models and Human Studies.

Author information

1
From the Longevity Institute and Leonard Davis School of Gerontology (H.M., S.D.B, V.D.L.), University of Southern California, Los Angeles, CA; and IFOM, FIRC Institute of Molecular Oncology, Via Adamello, 16, 20139 Milano, Italy (V.D.L.).
2
From the Longevity Institute and Leonard Davis School of Gerontology (H.M., S.D.B, V.D.L.), University of Southern California, Los Angeles, CA; and IFOM, FIRC Institute of Molecular Oncology, Via Adamello, 16, 20139 Milano, Italy (V.D.L.). vlongo@usc.edu.

Abstract

Recent studies indicate that dietary interventions have the potential to prevent and even treat cardiovascular disease, which is the leading cause of death. Many of these studies have focused on various animal models that are able to recreate one or more conditions or elevate risk factors that characterize the disease. Here, we highlight macronutrient-focused interventions in both mammalian model organisms and humans with emphasis on some of the most relevant and well-established diets known to be associated with cardiovascular disease prevention and treatment. We also discuss more recent dietary interventions in rodents, monkeys, and humans, which affect atherosclerosis and cardiovascular diseases with focus on those that also delay aging.

KEYWORDS:

CR; DR; FMD; health span; protein restriction

PMID:
27174953
DOI:
10.1161/CIRCRESAHA.116.307473
[Indexed for MEDLINE]

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