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Rev Alerg Mex. 2016 Apr-Jun;63(2):190-200.

[Evolution and phylogeny of B lymphocytes].

[Article in Spanish; Abstract available in Spanish from the publisher]

Author information

Centro de Investigaciones sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública, Secretaría de Salud, Cuernavaca, Morelos, México.


in English, Spanish

B lymphocytes are one of the most important cell types involved in the immune response of mammals. The origin and evolution of this cellular type is unknown, but the B lymphocyte bona fide appeared first in fish. In this review we analize the principal components of the immune response of invertebrates, their phylogenetic distribution and the permancence of some properties that allowed the emergence of the B lymphocyte. We started from the idea that many of the components that characterize the B lymphocyte are found distributed among the invertebrates, however, it is in the B lymphocyte, where all these components that give this type of cell its identity, converged. The actual knowledge we have in regards of the lymphocytes comes, in the most part, from physiological studies in mammals, being the mice the more representative. The origin of the B lymphocyte, its alternative mechanisms for generating receptor diversity, its immune effector response, and the generation of memory, require an evolutionary and multidisiplinary approach for its study.


B lymphocytes; evolution; invertebrates; phylogeny

[Indexed for MEDLINE]

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