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Rev Alerg Mex. 2016 Apr-Jun;63(2):163-8.

[Autoreactive TCD8+ lymphocytes in patients with chronic myeloid leukemia in association with HLA and adenovirus infection].

[Article in Spanish; Abstract available in Spanish from the publisher]

Author information

1
Universidad del Zulia, Maracaibo, Venezuela. sergio.rivera54@hotmail.es.

Abstract

in English, Spanish

BACKGROUND:

A possible interaction between a specific HLA type and Adenovirus has been postulated as a promoter in leukemia clonal evolution. The HLA-DRB1*14, specifically DRB1*14:21, 14:22, 14:45, 14:26, 14:33, 14:51, 14:35 subtypes was the most frequent in CML Venezuelan patients.

OBJECTIVES:

It is interesting to evaluate the molecular mimicry between the Adenovirus and the DRB1*14 subtypes which exhibit the same change in the amino acid position of the DR53 epitope. This mimicked segment has been identified as a LLERRRA polypeptide.

MATERIAL AND METHOD:

Experimental research conducted in the IHO Venezuela, in peripheral blood samples of patients with ALL, CML and healthy controls. Mixed culture, serology, lymphocyte proliferation and cytofluorometry were performed.

RESULTS:

DRB1*14 patient's lymphocytes reacted in 48 hours mixed culture against DRB1*14 promoters lymphocytes exhibiting increased CD8+T lymphocytes. CML patients show a different serological profile against Adenovirus. Only CML patients reacted to LLERRRA peptide, increasing CD8+ T cells.

CONCLUSION:

It is established that the relationship CML, HLADRB1* 14, autoreactive CD8+ T memory cell and CD8+T specific response from Adenovirus could be at the origin of the CML in Venezuelan patients.

KEYWORDS:

HLA association and disease; TCD4+; adenovirus; leukemias

PMID:
27174759
DOI:
10.29262/ram.v63i2.149
[Indexed for MEDLINE]

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