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Genet Mol Res. 2016 Apr 28;15(2). doi: 10.4238/gmr.15028007.

Analysis of interleukin 19 serum levels and single nucleotide polymorphisms in systemic lupus erythematosus.

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1
Department of Dermatology, Huashan Hospital Fudan University, Shanghai, China.

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disease that affects multiple organs and diminishes a patients' quality of life. It has been suggested that interleukin 19 (IL-19) is engaged in intercellular signal transduction, which is related to the immune response and the local inflammatory reaction. Single nucleotide polymorphisms (SNPs) have been used to explore the genetic basis underlying the pathogenesis of SLE. In this study, we investigated the potential correlation between the functional IL19 SNP rs2243188 and SLE. The frequency of allele C in rs2243188 was lower in the SLE population, particularly when the dominant inheritance model was applied. There was also a significant difference in the allele C frequency between the lupus nephritis (LN) and non-LN groups in both the dominant and recessive inheritance models. In addition, we identified significant differences in the serum IL-19 levels between the different classes of SLE. Although this study is still at the preliminary stage, the correlations between the IL19 SNP and SLE, and between the IL-19 levels and the different subclasses of SLE provide a reference for further exploration.

PMID:
27173295
DOI:
10.4238/gmr.15028007
[Indexed for MEDLINE]
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