Format

Send to

Choose Destination
Clin Chem. 2016 Jul;62(7):1020-31. doi: 10.1373/clinchem.2016.255828. Epub 2016 May 12.

Comparison of the Predictive Value of GlycA and Other Biomarkers of Inflammation for Total Death, Incident Cardiovascular Events, Noncardiovascular and Noncancer Inflammatory-Related Events, and Total Cancer Events.

Author information

1
Cardiovascular Division, School of Medicine, University of Minnesota, Minneapolis, MN; dupre007@umn.edu.
2
LabCorp, Raleigh, NC;
3
Department of Internal Medicine, Division of Nephrology, School of Medicine, University of Minnesota, Minneapolis, MN;
4
University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA;
5
Department of Pathology & Laboratory Medicine, and Biochemistry, University of Vermont College of Medicine, Colchester, VT;
6
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN.

Abstract

BACKGROUND:

GlycA is a biomarker that reflects integrated concentrations and glycosylation states of several acute-phase proteins. We studied the association of GlycA and inflammatory biomarkers with future death and disease.

METHODS:

A total of 6523 men and women in the Multi-Ethnic Study of Atherosclerosis who were free of overt cardiovascular disease (CVD) and in generally good health had a baseline blood sample taken. We assayed high-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), and d-dimer. A spectral deconvolution algorithm was used to quantify GlycA signal amplitudes from automated nuclear magnetic resonance (NMR) LipoProfileĀ® test spectra. Median follow-up was 12.1 years. Among 4 primary outcomes, CVD events were adjudicated, death was by death certificate, and chronic inflammatory-related severe hospitalization and death (ChrIRD) and total cancer were classified using International Classification of Diseases (ICD) codes. We used Poisson regression to study baseline GlycA, hsCRP, IL-6, and d-dimer in relation to total death, CVD, ChrIRD, and total cancer.

RESULTS:

Relative risk per SD of GlycA, IL-6, and d-dimer for total death (n = 915); for total CVD (n = 922); and for ChrIRD (n = 1324) ranged from 1.05 to 1.20, independently of covariates. In contrast, prediction from hsCRP was statistically explained by adjustment for other inflammatory variables. Only GlycA was predictive for total cancer (n = 663). Women had 7% higher values of all inflammatory biomarkers than men and had a significantly lower GlycA prediction coefficient than men in predicting total cancer.

CONCLUSIONS:

The composite biomarker GlycA derived from NMR is associated with risk for total death, CVD, ChrIRD, and total cancer after adjustment for hsCRP, IL-6, and d-dimer. IL-6 and d-dimer contribute information independently of GlycA.

PMID:
27173011
DOI:
10.1373/clinchem.2016.255828
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center