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J Agric Food Chem. 2016 Jun 8;64(22):4435-49. doi: 10.1021/acs.jafc.6b00857. Epub 2016 May 31.

Promising Health Benefits of the Strawberry: A Focus on Clinical Studies.

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Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche (DISCO)-Sez. Biochimica, Facoltà di Medicina, Università Politecnica delle Marche , 60131, Ancona, Italy.
Area de Nutrición y Salud, Universidad Internacional Iberoamericana (UNINI) , Campeche, C.P. 24040, Mexico.
Analytical and Food Chemistry Department, Faculty of Food Science and Technology, University of Vigo , E-32004 Ourense, Spain.
Dipartimento di Scienze Agrarie, Alimentari e Ambientali, Università Politecnica delle Marche , Via Ranieri 65, 60131 Ancona, Italy.
Department of Physiology, Institute of Nutrition and Food Technology ''José Mataix", Biomedical Research Centre, University of Granada , 18071 Granada, Spain.
Centre for Nutrition & Health, Universidad Europea del Atlantico (UEA) , Santander 39011, Spain.


The potential health benefits associated with dietary intake of fruits have attracted increasing interest. Among berries, the strawberry is a rich source of several nutritive and non-nutritive bioactive compounds, which are implicated in various health-promoting and disease preventive effects. A plethora of studies have examined the benefits of strawberry consumption, such as prevention of inflammation disorders and oxidative stress, reduction of obesity related disorders and heart disease risk, and protection against various types of cancer. This review provides an overview of their nutritional and non-nutritional bioactive compounds and which factors affect their content in strawberries. In addition, the bioavailability and metabolism of major strawberry phytochemicals as well as their actions in combating many pathologies, including cancer, metabolic syndrome, cardiovascular disease, obesity, diabetes, neurodegeneration, along with microbial pathogenesis have been reviewed, with a particular attention to human studies.


anti-inflammation; anticancer; antidiabetes; antimetabolic syndrome; antiobesity; cardioprotection; neuroprotection; phenolic compounds; strawberry

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