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BMC Cardiovasc Disord. 2016 May 11;16:92. doi: 10.1186/s12872-016-0266-7.

Serum levels of C1q/TNF-related protein-1 (CTRP-1) are closely associated with coronary artery disease.

Author information

1
Clinical Laboratory, The 305 Hospital of the People's Liberation Army, Beijing, 100017, China. huizhongwang86@126.com.
2
Clinical Laboratory, The 305 Hospital of the People's Liberation Army, Beijing, 100017, China.
3
Department of Cardiology, The 305 Hospital of the People's Liberation Army, Beijing, 100017, China.

Abstract

BACKGROUND:

Complement C1q tumor necrosis factor related proteins (CTRPs) have been proved to have diverse biological influences on cardiovascular system. CTRP 1 is a member of the CTRP superfamily, however, the relevance with coronary artery disease (CAD) are seldom explored. This study was designed to investigate the correlation between serum levels of CTRP 1 and CAD.

METHODS:

CTRP 1 levels of 150 CAD patients and 50 non-CAD subjects were determined by enzymelinked immunosorbent assay. Further analysis of CTRP 1 levels in different stages and lesion vessels of CAD were conducted.

RESULTS:

Serum levels of CTRP 1 in CAD patients were significantly elevated, and it was increased with the severity of CAD. CTRP 1 level in acute myocardial infarction group was much higher than that in stable/unstable angina and non-CAD groups. And significant differences of CTRP 1 were also found between single-vessel disease and triple-vessel disease. Multiple logistic regression analysis showed that CTRP 1 was an independent risk factor of the occurrence of myocardial infarction.

CONCLUSIONS:

Increased serum CTRP 1 levels were closely associated with the prevalence and severity of CAD, it might be regarded as a marker for myocardial infarction.

KEYWORDS:

Acute myocardial infarction; Complement C1q tumor necrosis factor related protein 1; Coronary artery disease

PMID:
27169633
PMCID:
PMC4865004
DOI:
10.1186/s12872-016-0266-7
[Indexed for MEDLINE]
Free PMC Article

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