Behav Brain Funct. 2016 May 12;12(1):14. doi: 10.1186/s12993-016-0098-8.

Oral administration of potassium bromate induces neurobehavioral changes, alters cerebral neurotransmitters level and impairs brain tissue of swiss mice.

Ajarem J¹, Altoom NG¹, Allam AA^1,², Maodaa SN¹, Abdel-Maksoud MA³, Chow BK⁴.

Author information

1: Department of Zoology, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.
2: Department of Zoology, Faculty of Science, Beni-suef University, Beni-Suef, Egypt.
3: Department of Zoology, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia. harrany@gmail.com.
4: School of Biological Sciences, University of Hong Kong, Hong Kong, China.

Abstract

BACKGROUND:

Potassium bromate (KBrO3) is widely used as a food additive and is a major water disinfection by-product. The present study reports the side effects of KBrO3 administration on the brain functions and behaviour of albino mice.

METHODS:

Animals were divided into three groups: control, low dose KBrO3 (100 mg/kg/day) and high dose KBrO3 (200 mg/kg/day) groups.

RESULTS:

Administration of KBrO3 led to a significant change in the body weight in the animals of the high dose group in the first, second and the last weeks while water consumption was not significantly changed. Neurobehavioral changes and a reduced Neurotransmitters levels were observed in both KBrO3 groups of mice. Also, the brain level of reduced glutathione (GSH) in KBrO3 receiving animals was decreased. Histological studies favoured these biochemical results showing extensive damage in the histological sections of brain of KBrO3-treated animals.