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Pak J Pharm Sci. 2016 May;29(3):837-42.

Antihyperglycemic effect of Persea duthieion blood glucose levels and body weight in alloxan induced diabetic rabbits.

Author information

1
Department of Chemistry, Kohat University of Science and Technology, Kohat, Pakistan.
2
Department of Pharmacy, Abdul Wali Khan University Mardan 23200, Pakistan.
3
Department of Zoology, Kohat University of Science & Technology, Kohat, Pakistan.
4
College of Veterinary Sciences and Animal Husbandry, Abdul Wali Khan University Mardan, Pakistan.

Abstract

The present study was designed to investigate the antihyperglycemic effect of Persea duthieion blood glucose concentration and body weight in alloxan induced diabetic hyperglycemic rabbits. The results illustrated significant antihyperglycemic activity of crude extract with 17.44% and 28.02% amelioration at 25 and 50mg/kg p.o. respectively after 24th day of drug treatment; equally supported by body weight recovery. Upon fractionation, most dominant antihyperglycemic effect was displayed by aqueous fraction with 22.12% and 34.43% effect followed by ethyl acetate fraction with 24.32% and 32.05% effect at 25 and 50mg/kg p.o. respectively after 24th day of drug treatment. The effect on blood glucose was also reflected on body weight of animals. In conclusion, our study documented marked antihyperglycemic activity of extract/fractions of P. duthiei.

PMID:
27166552
[Indexed for MEDLINE]

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