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J Clin Sleep Med. 2016 Jul 15;12(7):1027-32. doi: 10.5664/jcsm.5942.

Rapid Eye Movement Sleep Abnormalities in Children with Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS).

Author information

1
Department of Pediatrics and Developmental Neuroscience, National Institute of Mental Health, Bethesda, MD.
2
Pediatric Neuropsychiatry and Immunology Program, Massachusetts General Hospital, Harvard University School of Medicine, Boston, MA.
3
Child Study Center, Yale University School of Medicine, New Haven, CT.

Abstract

STUDY OBJECTIVES:

Polysomnographic investigation of sleep architecture in children presenting with pediatric acute-onset neuropsychiatric syndrome (PANS).

METHODS:

Fifteen consecutive subjects meeting criteria for PANS (mean age = 7.2 y; range 3-10 y) underwent single-night full polysomnography (PSG) read by a pediatric neurologist.

RESULTS:

Thirteen of 15 subjects (87%) had abnormalities detected with PSG. Twelve of 15 had evidence of rapid eye movement (REM) sleep motor disinhibition, as characterized by excessive movement, laughing, hand stereotypies, moaning, or the continuation of periodic limb movements during sleep (PLMS) into REM sleep.

CONCLUSIONS:

This study shows various forms of REM sleep motor disinhibition present in a population of children with PANS.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT01281969 NCT01778504.

KEYWORDS:

PANS; REM sleep behavior disorder; obsessive compulsive disorder; polysomnography

PMID:
27166296
PMCID:
PMC4918985
DOI:
10.5664/jcsm.5942
[Indexed for MEDLINE]
Free PMC Article

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