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Cancer Cell. 2016 May 9;29(5):613-615. doi: 10.1016/j.ccell.2016.04.007.

Head of the Class: OLIG2 and Glioblastoma Phenotype.

Author information

1
Department of Cancer Biology, Vanderbilt University School of Medicine, 761B Preston Research Building, 2220 Pierce Avenue, Nashville, TN 37232-6840, USA.
2
Department of Cancer Biology, Vanderbilt University School of Medicine, 761B Preston Research Building, 2220 Pierce Avenue, Nashville, TN 37232-6840, USA; Department of Neurological Surgery, Vanderbilt University School of Medicine, 761B Preston Research Building, 2220 Pierce Avenue, Nashville, TN 37232-6840, USA. Electronic address: rebecca.ihrie@vanderbilt.edu.

Abstract

Genomic mapping has driven the classification of glioblastoma into distinct molecular subclasses, but mechanisms that regulate tumor subclass phenotypes are only now emerging. In this issue of Cancer Cell, Lu et al. describe a phenotypic switch from PDGFRA-enriched "proneural" to EGFR-enriched "classical" features in glioblastoma upon ablation of Olig2.

PMID:
27165737
DOI:
10.1016/j.ccell.2016.04.007
[Indexed for MEDLINE]
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