Format

Send to

Choose Destination

RETRACTED ARTICLE

See: Retraction Notice

Molecules. 2016 May 5;21(5). pii: E594. doi: 10.3390/molecules21050594.

The Aminopyridinol Derivative BJ-1201 Protects Murine Hippocampal Cells against Glutamate-Induced Neurotoxicity via Heme Oxygenase-1.

Author information

1
College of Pharmacy, Chosun University, Dong-gu, Gwangju 61452, Korea. dslee2771@chosun.ac.kr.
2
Department of Pharmacy, Hanyang University, Ansan 15588, Korea. tnam@hanyang.ac.kr.
3
College of Pharmacy, Yeungnam University, Gyeongsan 38541, Korea. jeongb@ynu.ac.kr.
4
College of Pharmacy, Keimyung University, Daegu 42601, Korea. gsjeong@kmu.ac.kr.

Abstract

Glutamate is the major excitatory neurotransmitter in the brain. It can cause neuronal cell damage in the context of oxidative stress. BJ-1201 is a derivative of the compound aminopyridinol, which is known for its antioxidant activity. In this study, we examined the effect of BJ-1201, a 6-(diphenylamino)-2,4,5-trimethylpyridin-3-ol compound, on neuroprotection in HT22 cells. Our data showed that BJ-1201 can protect HT22 cells against glutamate-induced cell cytotoxicity. In addition, BJ-1201 upregulated heme oxygenase-1 (HO-1) to levels comparable to those of the CoPP-treated group. BJ-1201 treatment induced phosphorylation of JNK, but not p38-MAPK or ERK. It also increased the signal in the reporter assay based on β-galactosidase activity driven by the nuclear transcription factor erythroid-2 related factor 2 (Nrf2) promoter harboring antioxidant response elements (AREs) and induced the translocation of Nrf2. These results demonstrate that BJ-1201 may be a good therapeutic platform against neurodegenerative diseases induced by oxidative stress.

KEYWORDS:

aminopyridinol HT22; aminopyridinol compound BJ-1201; heme oxygenase-1; neuroprotection; nuclear transcription factor erythroid-2 related factor 2

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center