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Brain Stimul. 2016 Sep-Oct;9(5):705-711. doi: 10.1016/j.brs.2016.04.011. Epub 2016 Apr 14.

Effects of Theta Transcranial Alternating Current Stimulation Over the Frontal Cortex on Reversal Learning.

Author information

1
Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, The Netherlands. Electronic address: m.wischnewski@donders.ru.nl.
2
Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, The Netherlands.

Abstract

BACKGROUND:

Theta oscillations in the electroencephalogram (EEG) are associated with learning and behavioral adaptation.

OBJECTIVE:

To investigate the effects of theta transcranial alternating current stimulation (tACS) applied to the frontal cortex on reversal learning.

METHODS:

Healthy volunteers participated in a sham-controlled between subjects design. TACS at 1 mA peak-to-peak was administered during a reward-punishment reversal learning task. Resting state EEG was measured before and after tACS and the task.

RESULTS:

Active tACS improved learning ability, but at the same time interfered with applying the rule to optimize behavior. Furthermore, a significant decrease in frontal theta-beta EEG ratios was observed following active tACS.

CONCLUSIONS:

Results provide behavioral and electrophysiological evidence for influencing reversal learning with exogenous oscillatory electric field potentials applied to the frontal cortex.

KEYWORDS:

Electroencephalogram; Reversal learning; Theta activity; Theta–beta ratio; Transcranial alternating current stimulation

PMID:
27162098
DOI:
10.1016/j.brs.2016.04.011
[Indexed for MEDLINE]

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