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Urol Int. 2017;98(2):210-214. doi: 10.1159/000445839. Epub 2016 May 4.

Effects of Tadalafil 5 mg Dosed Once Daily in Men with Premature Ejaculation.

Author information

1
Department of Urology, Derince Training and Research Hospital, Kocaeli, Turkey.

Abstract

PURPOSE:

In this study, we evaluated the effect of 5 mg tadalafil once daily in men with premature ejaculation (PE).

METHODS:

Thirty married men with lifelong PE and 30 healthy men as control group were included in this study. All the patients received 5 mg tadalafil once a day for a month. The international index of erectile function questionnaire and intravaginal ejaculatory latency times (IELTs) and PE profile were recorded before and after treatment. Plasma samples were collected before and after treatment.

RESULTS:

The mean baseline IELTs was 40.8 ± 8.1 s in the PE group and 196.5 ± 26.2 s in the control group. After treatment in the PE group, the mean IELTs values showed a statistically significant improvement from the baseline values. At the end of 4 weeks, in the PE group, the mean IELT values showed a statistically significant improvement from the baseline values. Baseline serum nitric oxide (NO) levels were 27.3 ± 1.7 in the PE group and in the 31.1 ± 1.4 healthy control groups. After treatment, NO levels were increased from baseline.

CONCLUSION:

We consider that 5 mg tadalafil once daily is safety and effective for the treatment of PE.

PMID:
27160247
DOI:
10.1159/000445839
[Indexed for MEDLINE]

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