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J Reprod Med. 1989 Apr;34(4):264-6.

Autoimmunity as a factor in recurrent vaginal candidosis and the minor vestibular gland syndrome.

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  • 1Clinical Immunology Research Unit, Princess Margaret Hospital, Subiaco, Western Australia.


Chronic vaginal candidosis is a significant cause of morbidity in women, but its causes are not yet understood. We propose that in genetically susceptible women a candidal infection elicits responses that cross-react with self-antigens. Control of these deleterious responses may compromise the normal mechanisms of resistance and predispose to recurrent infection. Furthermore, the local inflammation caused by these autoreactive cells may contribute to other forms of vaginitis.

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