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J Pediatr. 2016 Jul;174:267-269.e1. doi: 10.1016/j.jpeds.2016.04.004. Epub 2016 May 4.

False Positive Lyme Disease IgM Immunoblots in Children.

Author information

1
Division of General Internal Medicine and Division of Pediatric Infectious Diseases, Duke University Medical Center, Durham, NC.
2
Division of Emergency Medicine, Boston Children's Hospital, Boston, MA.
3
Division of Emergency Medicine, Boston Children's Hospital, Boston, MA. Electronic address: Lise.nigrovic@childrens.harvard.edu.

Abstract

In our cross-sectional sample of 7289 serologic tests for Lyme disease, we identified 167 instances of a positive IgM immunoblot but a negative IgG immunoblot test result. Considering that only 71% (95% CI 64%-78%) of patients had Lyme disease, a positive IgM immunoblot alone should be interpreted with caution to avoid over-diagnosis of Lyme disease.

KEYWORDS:

Lyme disease; diagnostic tests; immunoblots; pediatrics

PMID:
27157898
PMCID:
PMC4925275
DOI:
10.1016/j.jpeds.2016.04.004
[Indexed for MEDLINE]
Free PMC Article

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