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PET Clin. 2012 Jul;7(3):263-74. doi: 10.1016/j.cpet.2012.04.003. Epub 2012 May 24.

(18)F NaF PET/CT in the Assessment of Malignant Bone Disease.

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Division of Nuclear Medicine, Stanford University Medical Center, 300 Pasteur Drive, H-2200, Stanford, CA 94305-5281, USA.


Diagnostic imaging plays a major role in the evaluation of patients with malignant bone disease. (18)F-Labeled sodium fluoride ((18)F NaF) is a positron-emitting radiopharmaceutical with desirable characteristics (rapid blood clearance and bone uptake) for high-quality functional imaging of the skeleton. In addition to higher sensitivity and specificity, (18)F NaF PET combined with computed tomography (PET/CT) allows for shorter imaging time, thus improving patients' convenience and benefiting the overall workflow of the imaging facility. Although as yet no robust evidence-based data exist, this article summarizes the published data currently available on the role of (18)F NaF PET/CT in the assessment of malignant bone disease.


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