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Rev Neurol (Paris). 2016 Apr-May;172(4-5):307-12. doi: 10.1016/j.neurol.2015.10.009. Epub 2016 May 4.

Semantic memory assessment in 15 patients with amyotrophic lateral sclerosis.

Author information

1
Service de neurologie, CHU de Dijon, 14, rue Gaffarel, 21000 Dijon, France. Electronic address: mariehervieu1024@aol.com.
2
Service de neurologie, CHU de Dijon, 14, rue Gaffarel, 21000 Dijon, France.
3
Service de neurologie, centre hospitalier William-Morey de Chalon-Sur-Saône, 4, rue Capitaine-Drillien, 71321 Chalon-Sur-Saône, France.

Abstract

INTRODUCTION:

A total of 30 to 50% of amyotrophic lateral sclerosis patients suffer from cognitive disorders. The aim of the study is to characterize these disorders and to assess semantic memory in non-demented ALS patients. The secondary aim is to look for a link between disease type and neuropsychological characteristics.

METHOD:

Patients were followed in an ALS center in Dijon. The following neuropsychological tests were used in this study: Folstein test, BREF test, verbal fluency, Isaac test, GRESEM test and TOP 30 test.

RESULTS:

Fifteen ALS patients were included. Nine of them (60%) were suffering from a semantic memory disorder. There was no correlation between ALS characteristics and the semantic memory disorder.

DISCUSSION:

This is the first study to reveal a semantic memory disorder in ALS. This result accentuates the hypothesis that ALS and semantic dementia are two phenotypes of the same degenerative process linked to TDP 43 proteinopathy.

KEYWORDS:

Amyotrophic lateral sclerosis; Semantic memory

PMID:
27157419
DOI:
10.1016/j.neurol.2015.10.009
[Indexed for MEDLINE]

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