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Cell Metab. 2016 May 10;23(5):893-900. doi: 10.1016/j.cmet.2016.04.012. Epub 2016 May 3.

A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs.

Author information

1
University of Cambridge Metabolic Research Laboratories, WT-MRC Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK. Electronic address: er311@cam.ac.uk.
2
University of Cambridge Metabolic Research Laboratories, WT-MRC Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.
3
MRC Epidemiology Unit, WT-MRC Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.
4
School of Clinical Medicine, University of Cambridge, Cambridge CB2 0SP, UK.
5
The Roslin Institute, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK; The Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK.
6
The Roslin Institute, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK.
7
Institute of Ageing and Chronic Disease, University of Liverpool, Neston, Cheshire CH64 7TE, UK.
8
Department of Canine Genetics, Animal Health Trust, Newmarket, Suffolk CB8 7UU, UK.
9
IMBIM, Uppsala University, Uppsala 75123, Sweden.
10
Department of Anatomy, Physiology, and Biochemistry, Swedish University of Agricultural Sciences, Uppsala 75007, Sweden.
11
Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala 75007, Sweden.
12
Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Science for Life Laboratory, Uppsala 75123, Sweden.
13
University of Cambridge Metabolic Research Laboratories, WT-MRC Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK. Electronic address: so104@medschl.cam.ac.uk.

Abstract

Sequencing of candidate genes for obesity in Labrador retriever dogs identified a 14 bp deletion in pro-opiomelanocortin (POMC) with an allele frequency of 12%. The deletion disrupts the β-MSH and β-endorphin coding sequences and is associated with body weight (per allele effect of 0.33 SD), adiposity, and greater food motivation. Among other dog breeds, the deletion was only found in the closely related flat-coat retriever (FCR), where it is similarly associated with body weight and food motivation. The mutation is significantly more common in Labrador retrievers selected to become assistance dogs than pets. In conclusion, the deletion in POMC is a significant modifier of weight and appetite in Labrador retrievers and FCRs and may influence other behavioral traits.

PMID:
27157046
PMCID:
PMC4873617
DOI:
10.1016/j.cmet.2016.04.012
[Indexed for MEDLINE]
Free PMC Article

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