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Behav Ther. 2016 May;47(3):416-30. doi: 10.1016/j.beth.2016.02.005. Epub 2016 Feb 24.

Transdiagnostic and Transcultural: Pilot Study of Unified Protocol for Depressive and Anxiety Disorders in Japan.

Author information

1
National Center for Cognitive Behavior Therapy and Research, National Center of Neurology and Psychiatry, Kodaira. Electronic address: masayait@ncnp.go.jp.
2
National Center for Cognitive Behavior Therapy and Research, National Center of Neurology and Psychiatry, Kodaira.
3
Kanto Junior College, Tatebayashi.
4
Tokyo Medical University.
5
National Center of Neurology and Psychiatry, Tokyo.
6
The Institute of Statistical Mathematics, Tachikawa.
7
Gifu University.
8
National Disaster Medical Center, Tachikawa.
9
Keio University School of Medicine.

Abstract

Unified protocol (UP) is a transdiagnostic cognitive behavior therapy for emotional disorders. It remains unknown whether UP is applicable for use in non-Western countries and for depressive disorders. We therefore examined its feasibility for a Japanese clinical population using this clinical trial design, which is multicentered, open-labeled, and single-armed (Clinical registry: UMIN000008322). The primary outcome was severity of anxiety symptoms, as assessed using Structured Interview Guide for the Hamilton Anxiety Rating Scale. Secondary outcomes were depressive symptoms, clinical global impression, functioning, quality of life, affectivity, emotion regulation, and adverse events. Of the 28 prospective participants, 17 were eligible and enrolled (depressive disorders=9, anxiety disorders=8). Severity of anxiety symptoms, which decreased significantly after the intervention, remained low for 3months (Hedges' g=1.29, 95% CI=0.56-2.06). Similar tendencies were observed for secondary outcome measures. No severe adverse event occurred. Two participants dropped out of the intervention. High treatment adherence and interrater reliability were confirmed. Results suggest the feasibility of UP in the Japanese context sufficient to warrant a larger clinical trial.

KEYWORDS:

anxiety disorder; cognitive behavioral therapy; culture; depressive disorder

PMID:
27157034
DOI:
10.1016/j.beth.2016.02.005
[Indexed for MEDLINE]

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