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Eur J Med Chem. 2016 Aug 25;119:141-68. doi: 10.1016/j.ejmech.2016.03.087. Epub 2016 Apr 2.

Recent developments of C-4 substituted coumarin derivatives as anticancer agents.

Author information

1
Centre for Pharmaceutical Sciences and Natural Products, School of Basic and Applied Sciences, Central University of Punjab, Bathinda, 151 001, India.
2
Centre for Pharmaceutical Sciences and Natural Products, School of Basic and Applied Sciences, Central University of Punjab, Bathinda, 151 001, India. Electronic address: vikasjaitak@gmail.com.

Abstract

Cancer is a prominent cause of death in global. Currently, the numbers of drugs that are in clinical practice are having a high prevalence of side effect and multidrug resistance. Researchers have made an attempt to expand a suitable anticancer drug that has no MDR and side effect. Coumarin scaffold became an attractive subject due to their broad spectrum of pharmacological activities. Coumarin derivatives extensively explored for anticancer activities as it possesses minimum side effect along with multi-drug reversal activity. Coumarin derivatives can act by various mechanisms on different tumor cell lines depending on substitution pattern of the core structure of coumarin. Substitution on coumarin nucleus leads to the search for more potent compounds. In this review, we have made an effort to give a synthetic strategy for the preparation of C-4 substituted coumarin derivatives as anticancer agents based on their mechanism of action and also discuss the SAR of the most active compound.

KEYWORDS:

Anticancer; C-4 substituted coumarin; Mechanism of action; SAR; Synthesis

PMID:
27155469
DOI:
10.1016/j.ejmech.2016.03.087
[Indexed for MEDLINE]

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