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J Med Virol. 2016 Dec;88(12):2078-2084. doi: 10.1002/jmv.24572. Epub 2016 Jul 27.

Seasonal influenza A/H3N2 virus infection and IL-1Β, IL-10, IL-17, and IL-28 polymorphisms in Iranian population.

Author information

1
Department of Virology, School of Public Health, Tehran University of Medical Sciences, International Campus, Tehran, Iran.
2
Department of Medical Laboratory Science, Faculty of Allied Health Sciences, College of Health Sciences, Bayero University Kano, Kano, Nigeria.
3
Department of Virology, School of Public Health, Tehran University of Medical Sciences, International Campus, Tehran, Iran. rezaei@tums.ac.ir.
4
National Influenza, Center Department of Medical Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. rezaei@tums.ac.ir.
5
Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
6
National Influenza, Center Department of Medical Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
7
Department of Virology, School of Public Health, Tehran University of Medical Sciences, International Campus, Tehran, Iran. mokhtari@sina.tums.ac.ir.
8
National Influenza, Center Department of Medical Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. mokhtari@sina.tums.ac.ir.

Abstract

Increased blood cytokines is the main immunopathological process that were attributed to severe clinical outcomes in cases of influenza A/H3N2 virus infection. The study was aimed to investigate the polymorphisms of IL-1β, IL-10, IL-17, and IL-28 genes to find the possibility of their association with the clinical outcome of influenza A/H3N2 virus infection among the infected patients in Iran. This is a Case-Control study in which influenza A/H3N2 virus positive confirmed with real-time PCR were the cases. DNA samples from groups were genotyped for polymorphisms in rs16944 (IL-1β), rs1800872 (IL-10), rs2275913 (IL-17), and rs8099917 (IL-28). Confidence interval (95%CI) and Odds ratio (OR) were calculated. IL-17 rs2275913 (GG and AG) were associated with risk of infection with that were statistically significant (P < 0.05, OR = 2.08-2.94). IL-1β (rs16944) (GG) was associated with reduced risk of infection (P < 0.01, OR = 0.46). Genotype GG and GT of IL-10 (rs1800872) were associated with increased risk of infection with influenza A/H3N2 virus (P < 0.05, OR = 2.04-2.58). In addition, IL-28 (rs8099917) genotypes GG (P < 0.05, OR = 0.49) and TG (P < 0.05, OR = 0.59) were associated with reduced risk of ILI symptom while genotype TT (P < 0.01, OR = 4.31) was associated with increased risk of ILI symptom. The results of this study demonstrated that polymorphisms of genes involved in the inflammatory and anti-inflammatory process affect the outcome of disease caused by influenza A/H3N2 virus. Thorough insight on host immune response at the time of influenza A virus infection is required to ensure adequate patient care in the case of feature outbreaks. J. Med. Virol. 88:2078-2084, 2016.

KEYWORDS:

IL-10; IL-17; IL-1β; IL-28; influenza A/H3N2 virus; polymorphism

PMID:
27155288
DOI:
10.1002/jmv.24572
[Indexed for MEDLINE]

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