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J Physiol Biochem. 2016 Sep;72(3):371-80. doi: 10.1007/s13105-016-0492-6. Epub 2016 May 6.

The role of sirtuins in cellular homeostasis.

Author information

1
Department of Biochemistry and Genetics, Institute of Biology, Jan Kochanowski University, ul. Świętokrzyska 15, 25-406, Kielce, Poland.
2
Department of Biochemistry and Genetics, Institute of Biology, Jan Kochanowski University, ul. Świętokrzyska 15, 25-406, Kielce, Poland. jan.palyga@ujk.edu.pl.
3
Institute of Plant Physiology, Polish Academy of Sciences, Niezapominajek 21, 30-239, Kraków, Poland.

Abstract

Sirtuins are evolutionarily conserved nicotinamide adenine dinucleotide (NAD(+))-dependent lysine deacylases or ADP-ribosyltransferases. These cellular enzymes are metabolic sensors sensitive to NAD(+) levels that maintain physiological homeostasis in the animal and plant cells.

KEYWORDS:

Deacetylation; Deacylation; Mammalian and plant sirtuins; Mono-ADP-ribosylation; Sirtuin activators and inhibitors

PMID:
27154583
PMCID:
PMC4992043
DOI:
10.1007/s13105-016-0492-6
[Indexed for MEDLINE]
Free PMC Article

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