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Genome Biol. 2016 May 6;17(1):91. doi: 10.1186/s13059-016-0953-9.

High-performance web services for querying gene and variant annotation.

Author information

1
Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA.
2
Current address: Avera Cancer Institute, 11099 North Torrey Pines Road, La Jolla, CA, 92037, USA.
3
Department of Biomedical Informatics and Medical Education, The University of Washington, Box SLU-BIME 358047, Seattle, WA, 98195, USA.
4
McDonnell Genome Institute, Washington University School of Medicine, 4444 Forest Park Ave, St. Louis, MO, 63108, USA.
5
Department of Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA.
6
The Scripps Translational Science Institute, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA.
7
Center for Research in Biological Systems, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
8
Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA, 94720, USA.
9
Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA. asu@scripps.edu.
10
The Scripps Translational Science Institute, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA. asu@scripps.edu.
11
Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA. cwu@scripps.edu.

Abstract

Efficient tools for data management and integration are essential for many aspects of high-throughput biology. In particular, annotations of genes and human genetic variants are commonly used but highly fragmented across many resources. Here, we describe MyGene.info and MyVariant.info, high-performance web services for querying gene and variant annotation information. These web services are currently accessed more than three million times permonth. They also demonstrate a generalizable cloud-based model for organizing and querying biological annotation information. MyGene.info and MyVariant.info are provided as high-performance web services, accessible at http://mygene.info and http://myvariant.info . Both are offered free of charge to the research community.

KEYWORDS:

API; Annotation; Cloud; Database; Gene; Repository; Variant

PMID:
27154141
PMCID:
PMC4858870
DOI:
10.1186/s13059-016-0953-9
[Indexed for MEDLINE]
Free PMC Article

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