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Bioinformatics. 2016 Sep 15;32(18):2866-8. doi: 10.1093/bioinformatics/btw230. Epub 2016 Apr 25.

Combenefit: an interactive platform for the analysis and visualization of drug combinations.

Author information

1
CRUK Cambridge Institute, University of Cambridge, Cambridge, UK Early Clinical Development, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Cambridge, UK.
2
CRUK Cambridge Institute, University of Cambridge, Cambridge, UK.
3
Bioinformatics, Oncology Innovative Medicines, AstraZeneca, Cambridge, UK.

Abstract

MOTIVATION:

Many drug combinations are routinely assessed to identify synergistic interactions in the attempt to develop novel treatment strategies. Appropriate software is required to analyze the results of these studies.

RESULTS:

We present Combenefit, new free software tool that enables the visualization, analysis and quantification of drug combination effects in terms of synergy and/or antagonism. Data from combinations assays can be processed using classical Synergy models (Loewe, Bliss, HSA), as single experiments or in batch for High Throughput Screens. This user-friendly tool provides laboratory scientists with an easy and systematic way to analyze their data. The companion package provides bioinformaticians with critical implementations of routines enabling the processing of combination data.

AVAILABILITY AND IMPLEMENTATION:

Combenefit is provided as a Matlab package but also as standalone software for Windows (http://sourceforge.net/projects/combenefit/).

CONTACT:

Giovanni.DiVeroli@cruk.cam.ac.uk

SUPPLEMENTARY INFORMATION:

Supplementary data are available at Bioinformatics online.

PMID:
27153664
PMCID:
PMC5018366
DOI:
10.1093/bioinformatics/btw230
[Indexed for MEDLINE]
Free PMC Article

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