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Bioinformatics. 2016 Aug 1;32(15):2386-8. doi: 10.1093/bioinformatics/btw141. Epub 2016 Mar 12.

FRODOCK 2.0: fast protein-protein docking server.

Author information

1
Department of Biological Chemical Physics, Rocasolano Physical Chemistry Institute C.S.I.C, Madrid 28006, Spain Centro de Investigaciones Biológicas, CSIC, Madrid E-28040, Spain.
2
Department of Biological Chemical Physics, Rocasolano Physical Chemistry Institute C.S.I.C, Madrid 28006, Spain.

Abstract

The prediction of protein-protein complexes from the structures of unbound components is a challenging and powerful strategy to decipher the mechanism of many essential biological processes. We present a user-friendly protein-protein docking server based on an improved version of FRODOCK that includes a complementary knowledge-based potential. The web interface provides a very effective tool to explore and select protein-protein models and interactively screen them against experimental distance constraints. The competitive success rates and efficiency achieved allow the retrieval of reliable potential protein-protein binding conformations that can be further refined with more computationally demanding strategies.

AVAILABILITY AND IMPLEMENTATION:

The server is free and open to all users with no login requirement at http://frodock.chaconlab.org

CONTACT:

pablo@chaconlab.org

SUPPLEMENTARY INFORMATION:

Supplementary data are available at Bioinformatics online.

PMID:
27153583
DOI:
10.1093/bioinformatics/btw141
[Indexed for MEDLINE]

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