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Mol Cell. 2016 May 5;62(3):327-334. doi: 10.1016/j.molcel.2016.03.034.

RNA Polymerase Collision versus DNA Structural Distortion: Twists and Turns Can Cause Break Failure.

Author information

1
USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, 1441 Eastlake Ave, Room 5428, Los Angeles, CA 90089, USA.
2
USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, 1441 Eastlake Ave, Room 5428, Los Angeles, CA 90089, USA. Electronic address: lieber@usc.edu.

Abstract

The twisting of DNA due to the movement of RNA polymerases is the basis of numerous classic experiments in molecular biology. Recent mouse genetic models indicate that chromosomal breakage is common at sites of transcriptional turbulence. Two key studies on this point mapped breakpoints to sites of either convergent or divergent transcription but arrived at different conclusions as to which is more detrimental and why. The issue hinges on whether DNA strand separation is the basis for the chromosomal instability or collision of RNA polymerases.

PMID:
27153532
PMCID:
PMC4860253
DOI:
10.1016/j.molcel.2016.03.034
[Indexed for MEDLINE]
Free PMC Article

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