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Cell. 2016 May 5;165(4):827-41. doi: 10.1016/j.cell.2016.04.055.

Maternal IgG and IgA Antibodies Dampen Mucosal T Helper Cell Responses in Early Life.

Author information

1
Division of Immunology & Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley CA, 94720, USA.
2
Division of Immunology & Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley CA, 94720, USA. Electronic address: barton@berkeley.edu.

Abstract

To maintain a symbiotic relationship between the host and its resident intestinal microbiota, appropriate mucosal T cell responses to commensal antigens must be established. Mice acquire both IgG and IgA maternally; the former has primarily been implicated in passive immunity to pathogens while the latter mediates host-commensal mutualism. Here, we report the surprising observation that mice generate T cell-independent and largely Toll-like receptor (TLR)-dependent IgG2b and IgG3 antibody responses against their gut microbiota. We demonstrate that maternal acquisition of these antibodies dampens mucosal T follicular helper responses and subsequent germinal center B cell responses following birth. This work reveals a feedback loop whereby T cell-independent, TLR-dependent antibodies limit mucosal adaptive immune responses to newly acquired commensal antigens and uncovers a broader function for maternal IgG.

PMID:
27153495
PMCID:
PMC4866587
DOI:
10.1016/j.cell.2016.04.055
[Indexed for MEDLINE]
Free PMC Article

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