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Cell Stem Cell. 2016 May 5;18(5):573-86. doi: 10.1016/j.stem.2016.04.013.

Induced Pluripotent Stem Cells Meet Genome Editing.

Author information

1
Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: hockemeyer@berkeley.edu.
2
The Whitehead Institute for Biomedical Research and Department of Biology, MIT, Cambridge, MA 02142, USA.

Abstract

It is extremely rare for a single experiment to be so impactful and timely that it shapes and forecasts the experiments of the next decade. Here, we review how two such experiments-the generation of human induced pluripotent stem cells (iPSCs) and the development of CRISPR/Cas9 technology-have fundamentally reshaped our approach to biomedical research, stem cell biology, and human genetics. We will also highlight the previous knowledge that iPSC and CRISPR/Cas9 technologies were built on as this groundwork demonstrated the need for solutions and the benefits that these technologies provided and set the stage for their success.

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