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J Stroke Cerebrovasc Dis. 2016 Jul;25(7):1760-1766. doi: 10.1016/j.jstrokecerebrovasdis.2016.02.025. Epub 2016 Apr 14.

Susceptibility-Diffusion Mismatch in Hyperacute Stroke: Correlation with Perfusion-Diffusion Mismatch and Clinical Outcome.

Author information

1
Department of Diagnostic and Interventional Neuroradiology, Bretonneau University Hospital, Tours, France. Electronic address: maelle.d@hotmail.fr.
2
Department of Diagnostic and Interventional Neuroradiology, Bretonneau University Hospital, Tours, France.
3
Department of Neurology, Bretonneau University Hospital, Tours, France.

Abstract

BACKGROUND:

A prominent vein (PV) on susceptibility-weighted imaging (SWI) was recently proposed to be a marker of the penumbra. We aimed to compare the utility of SWI and perfusion-weighted imaging (PWI) sequences for the evaluation of the penumbra in hyperacute middle cerebral artery (MCA) stroke, and to determine whether SWI-DWI mismatch is a neuroimaging marker of clinical outcome.

METHODS:

A total of 149 consecutive patients with MCA stroke were prospectively enrolled. Magnetic resonance imaging (MRI) was performed within 6 hours of the onset of stroke. The ASPECTS values on diffusion-weighted imaging (DWI), PWI (delayed mean transit time), and SWI (visualization of PVs) were calculated by 2 independent raters. Correlation between PWI-ASPECTS and SWI-ASPECTS was calculated with the Pearson coefficient. Reliability of the PV rating system was calculated by an intraclass correlation coefficient (ICC). Favorable outcome was defined as a modified Rankin Scale score of 0-2 at 3 months for the 88 patients who received thrombolytic therapy.

RESULTS:

The ASPECTS-SWI and ASPECTS-PWI scores showed a good correlation (Pearson coefficient of .69, P <.001). The reproducibility between the findings of the junior and the senior radiologists was excellent with an ICC of .89 (confidence interval of 95% (IC95): .85-.92, P <.001). However, neither SWI-DWI mismatch nor PWI-SWI mismatch was associated with clinical outcome.

CONCLUSION:

SWI and PWI were complementary but not commutable for the assessment of the penumbra. Susceptibility-diffusion mismatch was not found in this study to have predictive value for stroke outcome.

KEYWORDS:

Rankin scale; Susceptibility-weighted imaging; penumbra; prominent veins; stroke

[Indexed for MEDLINE]

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