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Phytother Res. 2016 Aug;30(8):1339-44. doi: 10.1002/ptr.5635. Epub 2016 May 6.

Flaxseed Supplementation in Metabolic Syndrome Management: A Pilot Randomized, Open-labeled, Controlled Study.

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Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Clinical Nutrition, School of Nutrition & Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Liver & Hepatobiliary Diseases Research Center, Digestive Diseases Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.


The aim of this study was to evaluate the efficacy of flaxseed supplementation plus lifestyle modification in comparison with lifestyle modification alone in the management of metabolic syndrome (MetS). A randomized controlled clinical trial was conducted on 44 patients with MetS. Participants were assigned to receive either the lifestyle advice and 30-g brown milled flaxseed daily or only the lifestyle advice as the control group. The percentage of individuals with MetS decreased from baseline by 50% and 82% in the control and intervention group, respectively. The reversion rate of central obesity was higher in the flaxseed group (36%) than control group (13%). Moreover, greater reduction in insulin resistance was observed in flaxseed group in comparison with control group (p < 0.001). Body weight, waist circumference, and body mass index decreased significantly in both groups with a significantly greater reduction in flaxseed group in comparison with controls (p < 0.05). There were no significant changes in blood pressure in any groups. Our results indicate that co-administration of flaxseed with lifestyle modification is more effective than lifestyle modification alone in management of MetS; whether these effects will be sustained with longer treatment durations remains to be determined.


central obesity; flaxseed; insulin resistance; metabolic syndrome

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